Highlights from the Biology of Genomes meeting

Highlights from the Biology of Genomes meeting

A recordsetting genome for a towering giant

Deciphering the genome of the loblolly pine is a tall order, as is perhaps fitting for a tree that can grow to be 30 meters in height.

Researchers sequenced the conifers Pinus taeda approximately 24 billion bases of DNA, Steven Salzberg of Johns Hopkins University reported May 10. That surpasses the previous record holder, wheat, by more than 7 billion bases. The DNA is distributed over 12 chromosomes, each about twothirds the size of the entire human genome.

A preliminary analysis suggests the trees may have up to 64,000 proteincoding genes, although Salzberg says the number is probably smaller. Humans have just over 22,000 proteincoding genes.

Next, the researchers will tackle the sugar pine genome. That one is even bigger, with more than 35 billion DNA bases.

Strong swimming sperms secret

A gene variant can make sperm strong and speedy, a study of wild mice suggests.

Researchers compared two species of wild mice one promiscuous, one monogamous to learn how genetic factors produce physical characteristics that may give one species an evolutionary edge.

By pitting sperm from the two species against each other in a race to the top of a test tube, Hopi Hoekstra, a Harvard University evolutionary geneticist, and her group found that the fastest sperm are ones that have tails with a longer midsection. Hoekstra reported May 9 that the team traced the genetic source of that structural difference to a variant in the PRKAR1A gene. In people, male infertility can accompany mutations in that gene.

The genes activity is higher in hybrid males carrying at least one copy of the promiscuous species version than in males with two copies the monogamous version. And males with the promiscuous gene produce sperm with longer midsections and appear to have a mating advantage even when no other males are around. Of the males that sired pups when left alone with a female for a week, 45 percent carried two copies of the promiscuous species version of the gene, while only 25 percent had two copies of the monogamous species version.

In and out of Africa

Migration out of Africa wasnt a oneway journey, a new study suggests. In about 1,000 BC, a large group of people made the reverse trek from the Middle East into eastern Africa, evolutionary geneticist Joseph Pickrell of Harvard Medical School reported May 11.

Those migrants mixed with east Africans, and their descendants carried their genetic heritage into southern Africa.

Pickrell and his colleagues discovered the backtoAfrica migration while investigating a genetic connection between Italians and some southern Africans. Shared genetic variants between southern Europeans and Africans could mean that factions of the original Middle Eastern population migrated both into Africa and into Europe.

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